Karlsruhe Institute of Technology (KIT) မွ သိပၸံပညာရွင္မ်ားသည္ ဖန္တီးျပဳလုပ္ထားေသာ ႐ိုးတြင္းခ်ဥ္ဆီပံုစံတစ္မ်ိဳးကို ဖန္တီးျပဳလုပ္ႏုိင္ခဲ့သျဖင့္ ေသြးကင္ဆာေ၀ဒနာရွင္မ်ားအတြက္ ေမွ်ာ္လင့္ခ်က္တစ္ရပ္ကို ရွင္သန္ေစခဲ့သည္။ KIT မွ သိပၸံပညာရွင္ Max Planakႏွင့္ အဖြဲ႕သည္ သဘာ၀႐ုိုးတြင္းခ်ဥ္ဆီ၏ အေျခခံဂုဏ္သတိၱမ်ား ပါ၀င္ေသာ လူလုပ္႐ိုးတြင္းခ်ဥ္ဆီကို တီထြင္ႏိုင္ခဲ့ျခင္းျဖစ္သည္။
႐ိုးတြင္းခ်ဥ္ဆီတြင္ပါ၀င္ေသာ ေသြးဆဲလ္မူလပံုစံမ်ားသည္ ေသြးနီဥ၊ ေသြးျဖဴဥႏွင့္ ေသြးဥမႊားမ်ား၏ အေျခခံတည္ေဆာက္မႈကို ျဖစ္ေပၚေစႏိုင္သည့္အျပင္ ပ်က္စီးေနေသာ ေသြးဆဲလ္မ်ားကို အစားထိုးႏိုင္သျဖင့္ ေသြးကင္ဆာေရာဂါမ်ားတြင္ အစားထိုးကုသမႈျပဳလုပ္ေလ့ရွိသည္။ သို႔ေသာ္႐ုိးတြင္းခ်ဥ္ဆီ အလွဴရွင္ႏွင့္အလွဴခံလူနာအၾကားလိုက္ဖက္ရမည့္၊ တူညီရမည့္အခ်က္မ်ားစြာ ရွိေနေပသည္။ ထိုအခ်က္ကို ေျဖရွင္းႏုိင္ရန္ ေသြးဆဲလ္မ်ား၏ မူလျဖစ္တည္ရာ ႐ိုးတြင္းခ်ဥ္ဆီ၏ ဖြဲ႕စည္းပံုႏွင့္ ပါ၀င္ပစၥည္းမ်ားကို အတုယူတည္ေဆာက္ထားသည့္ synthetic polymer မ်ားကိုအသံုးျပဳထားေသာ လူလုပ္႐ိုးတြင္းခ်ဥ္ဆီကို ဖန္တီးခဲ့ျခင္းျဖစ္ေၾကာင္း Max Planak က ေျပာၾကားခဲ့သည္။
ယခုဖန္တီးမႈတြင္ သုေတသီမ်ားသည္ ေမြးကင္းစ ကေလးမ်ား၏ ခ်က္ႀကိဳးေသြးမွ အထူးျပဳခ်ဥ္ဆီဆဲလ္မ်ားကို အသံုးျပဳခဲ့ၿပီး ဓာတ္ခြဲခန္းတြင္ ေမြးျမဴကာ ထုတ္လုပ္ႏိုင္ခဲ့ျခင္းျဖစ္သည္။ ထိုသို႔ ပြားမ်ားရရွိလာသည့္ ခ်ဥ္ဆီဆဲလ္အသစ္မ်ားကို ဖန္တီးျပဳလုပ္ထားသည့္ ႐ိုးတြင္းခ်ဥ္ဆီတြင္ ထည့္သြင္းခဲ့ရာ ေအာင္ျမင္ခဲ့သည္။ ယခုအခါ ႂကြက္မ်ား တြင္စမ္းသပ္ခဲ့ရာ ဖန္တီးထားေသာ လူလုပ္႐ိုးတြင္းခ်ဥ္ ဆီသည္ ေသြးကင္ဆာျဖစ္ပြားေနေသာ ႂကြက္မ်ား၏ ေသြးဆဲလ္မ်ားကို အစားထိုးႏိုင္ခဲ့ေၾကာင္း သိရွိရသည္။
ယခုတီထြင္မႈကို Journal of Hoematology တြင္ ေဖာ္ျပထားျခင္းျဖစ္သည္။
သန္႔စင္
Scientists Develop Artificial Bone MarrowBy IndiaTimes
BERLIN: German scientists have developed artificial bone marrow that allows stem cells to multiply and may simplify the treatment of leukaemia.
The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory. This might facilitate the treatment of leukaemia in a few years, researchers said.
Scientists at Karlsruhe Institute of Technology (KIT), the Max Planck Institute for Intelligent Systems, Stuttgart, and Tubingen University developed the synthetic material that allows stem cells to multiply.
Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by haematopoietic stem cells located in a specialised niche of the bone marrow. Haematopoietic stem cells can be used for the treatment of blood diseases, such as leukaemia. The affected cells of the patient are replaced by healthy haematopoietic stem cells of an eligible donor.
However, not every leukaemia patient can be treated in this way, as the number of appropriate transplants is not sufficient. This problem might be solved by the reproduction of haematopoietic stem cells. So far, this has been impossible, as these cells retain their stem cell properties in their natural environment only, i.e. in their niche of the bone marrow.
Researchers artificially reproduced major properties of natural bone marrow at the laboratory. With the help of synthetic polymers, scientists created a porous structure simulating the sponge-like structure of the bone in the area of the blood-forming bone marrow.
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